Crenactin forms actin-like double helical filaments regulated by arcadin-2

@inproceedings{Izor2016CrenactinFA,
  title={Crenactin forms actin-like double helical filaments regulated by arcadin-2},
  author={Thierry Izor{\'e} and Danguole Kureisaite-Ciziene and Stephen H McLaughlin and Jan L{\"o}we},
  booktitle={eLife},
  year={2016}
}
The similarity of eukaryotic actin to crenactin, a filament-forming protein from the crenarchaeon Pyrobaculum calidifontis supports the theory of a common origin of Crenarchaea and Eukaryotes. Monomeric structures of crenactin and actin are similar, although their filament architectures were suggested to be different. Here we report that crenactin forms bona fide double helical filaments that show exceptional similarity to eukaryotic F-actin. With cryo-electron microscopy and helical… CONTINUE READING