Creeping baselines and adaptive resistance to antibiotics.

  title={Creeping baselines and adaptive resistance to antibiotics.},
  author={Luc{\'i}a Fern{\'a}ndez and Elena B. M. Breidenstein and Robert E. Hancock},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  volume={14 1},
The introduction of antimicrobial drugs in medicine gave hope for a future in which all infectious diseases could be controlled. Decades later it appears certain this will not be the case, because antibiotic resistance is growing relentlessly. Bacteria possess an extraordinary ability to adapt to environmental challenges like antimicrobials by both genetic and phenotypic means, which contributes to their evolutionary success. It is becoming increasingly appreciated that adaptation is a major… CONTINUE READING