Creb coactivators direct anabolic responses and enhance performance of skeletal muscle.

@article{Bruno2014CrebCD,
  title={Creb coactivators direct anabolic responses and enhance performance of skeletal muscle.},
  author={Nelson E Bruno and Kimberly A Kelly and Richard Hawkins and Mariam Bramah-Lawani and Antonio L. Amelio and Jerome C Nwachukwu and Kendall W Nettles and Michael D. Conkright},
  journal={The EMBO journal},
  year={2014},
  volume={33 9},
  pages={1027-43}
}
During the stress response to intense exercise, the sympathetic nervous system (SNS) induces rapid catabolism of energy reserves through the release of catecholamines and subsequent activation of protein kinase A (PKA). Paradoxically, chronic administration of sympathomimetic drugs (β-agonists) leads to anabolic adaptations in skeletal muscle, suggesting that sympathetic outflow also regulates myofiber remodeling. Here, we show that β-agonists or catecholamines released during intense exercise… CONTINUE READING
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