Creation of murine experimental abdominal aortic aneurysms with elastase.

@article{Azuma2009CreationOM,
  title={Creation of murine experimental abdominal aortic aneurysms with elastase.},
  author={Junya Azuma and Tomoko Asagami and Ronald L. Dalman and Philip S. Tsao},
  journal={Journal of visualized experiments : JoVE},
  year={2009},
  volume={29}
}
Transient intraluminal infusion of porcine pancreatic elastase into the infrarenal segment of the abdominal aorta is the most widely used animal model of abdominal aortic aneurysm (AAA) ever since it was first described in rats by Anidjar and colleagues.(1) The rationale for its development was based on the disrupted nature of elastin observed in AAAs. This rat model has been modified to produce AAAs in the infrarenal aortic region of mice.(2) The model has the ability to add broad insight into… CONTINUE READING