Creation of artificial protein–protein interactions using α-helices as interfaces

Abstract

Designing novel protein–protein interactions (PPIs) with high affinity is a challenging task. Directed evolution, a combination of randomization of the gene for the protein of interest and selection using a display technique, is one of the most powerful tools for producing a protein binder. However, the selected proteins often bind to the target protein at… (More)
DOI: 10.1007/s12551-017-0352-9

Topics

7 Figures and Tables