Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

@article{Gibson2010CreationOA,
  title={Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome},
  author={D. G. Gibson and J. Glass and C. Lartigue and V. Noskov and R. Chuang and Mikkel A. Algire and G. A. Benders and M. Montague and Li Ma and Monzia Moodie and C. Merryman and S. Vashee and R. Krishnakumar and Nacyra Assad-Garc{\'i}a and C. Andrews-Pfannkoch and E. A. Denisova and L. Young and Z. Qi and Thomas H Segall-Shapiro and C. Calvey and P. Parmar and C. Hutchison and Hamilton O. Smith and J. Venter},
  journal={Science},
  year={2010},
  volume={329},
  pages={52 - 56}
}
Let There Be Life The DNA sequence information from thousands of genomes is stored digitally as ones and zeros in computer memory. Now, Gibson et al. (p. 52, published online 20 May; see the cover; see the Policy Forum by Cho and Relman) have brought together technologies from the past 15 years to start from digital information on the genome of Mycoplasma mycoides to chemically synthesize the genomic DNA as segments that could then be assembled in yeast and transplanted into the cytoplasm of… Expand
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