Creatinine normalization in biological monitoring revisited: the case of 1-hydroxypyrene.

  title={Creatinine normalization in biological monitoring revisited: the case of 1-hydroxypyrene.},
  author={Claude Viau and Michel Lafontaine and J P Payan},
  journal={International archives of occupational and environmental health},
  volume={77 3},
OBJECTIVES To compare the apparent urinary excretion rates of both creatinine and 1-hydroxypyrene (1-OHP) and to assess the value of creatinine normalization for both toxicokinetic analysis and the routine examination of workers. METHODS All urine samples were collected from individuals who had been exposed to polycyclic aromatic hydrocarbons (PAHs), occupationally and non-occupationally, for at least 24 consecutive hours. Urinary creatinine and 1-OHP were determined. 1-OHP excretion rates… CONTINUE READING


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