Creatinine clearance: an inadequate marker of renal filtration in patients with early posthepatitic cirrhosis (Child A) without fluid retention and muscle wasting.

@article{DeSanto1995CreatinineCA,
  title={Creatinine clearance: an inadequate marker of renal filtration in patients with early posthepatitic cirrhosis (Child A) without fluid retention and muscle wasting.},
  author={N. G. DeSanto and P. Anastasio and C. Loguercio and L. Spitali and C. Del Vecchio Blanco and M. Corvinelli and M. Cirillo},
  journal={Nephron},
  year={1995},
  volume={70 4},
  pages={
          421-4
        }
}
Glomerular filtration rate (GFR) was measured in 19 patients with Child A liver cirrhosis by comparing the endogenous creatinine clearance with inulin clearance. Inulin clearance averaged 90 +/- 4.4 ml/min x 1.73 m2, while creatinine clearance averaged 122 +/- 7 ml/min x 1.73 m2 (p < 0.001). The overestimation of GFR by creatinine was present in 18 of 19 patients and was inversely correlated with inulin clearance (r = -0.452, p < 0.04). The data point to the unsuitability of creatinine as a… Expand
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