Creating permissive microenvironments for stem cell transplantation into the central nervous system.

@article{Kim2012CreatingPM,
  title={Creating permissive microenvironments for stem cell transplantation into the central nervous system.},
  author={Howard Kim and M. Jennifer Cooke and Molly S Shoichet},
  journal={Trends in biotechnology},
  year={2012},
  volume={30 1},
  pages={55-63}
}
Traumatic injury to the central nervous system (CNS) is highly debilitating, with the clinical need for regenerative therapies apparent. Neural stem/progenitor cells (NSPCs) are promising because they can repopulate lost or damaged cells and tissues. However, the adult CNS does not provide an optimal milieu for exogenous NSPCs to survive, engraft, differentiate, and integrate with host tissues. This review provides an overview of tissue engineering strategies to improve stem cell therapies by… CONTINUE READING
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