Creating conditional mutations in mammals

  title={Creating conditional mutations in mammals},
  author={David M. Spenci},
REVIEWS A lurid understanding of the labyrinthine complex- ities of intracellular signaling networks is an important prerequisite for manipulating signaling and. thus, gene expression. Paradoxically, the ability to regulate the activity of a protein within a signaling cascade provides a powerful aid towards elucidating the contextual role of that protein. While gene ablation and transgenic mice expressing constitutively active or dominant- negative molecules have provided insight into the… CONTINUE READING

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