Creating alignment and anisotropy in engineered heart tissue: role of boundary conditions in a model three-dimensional culture system.

Abstract

Electrical and mechanical anisotropy arise from matrix and cellular alignment in native myocardium. Generation of anisotropy in engineered heart tissue will be required to match native properties and will provide immediate opportunities to investigate the genesis and structural determinants of functional anisotropy. We investigated the influence of geometry… (More)

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