Creating a prosurvival phenotype through a histone deacetylase inhibitor in a lethal two-hit model.

@article{Liu2014CreatingAP,
  title={Creating a prosurvival phenotype through a histone deacetylase inhibitor in a lethal two-hit model.},
  author={Zhengcai Liu and Yongqing Li and Wei E. Chong and Danielle K Deperalta and Xiuzhen Duan and Baoling Liu and Ihab F. Halaweish and Peter X Zhou and Hasan B Alam},
  journal={Shock},
  year={2014},
  volume={41 2},
  pages={104-8}
}
OBJECTIVES Hemorrhagic shock (HS) can initiate an exaggerated systemic inflammatory response and multiple organ failure, especially if followed by a subsequent inflammatory insult ("second hit"). We have recently shown that histone deacetylase inhibitors can improve survival in rodent models of HS or septic shock, individually. In the present study, we examined whether valproic acid (VPA), a histone deacetylase inhibitor, could prolong survival in a rodent "two-hit" model: HS followed by septic… CONTINUE READING