Creating a functional single-chromosome yeast

@article{Shao2018CreatingAF,
  title={Creating a functional single-chromosome yeast},
  author={Yangyang Shao and Ning Lu and Zhenfang Wu and Chen Cai and Shanshan Wang and Ling-li Zhang and Fan Zhou and Shijun Xiao and Lin Liu and Xiaofei Zeng and Huajun Zheng and Chen Yang and Zhihu Zhao and Guoping Zhao and Jinhui Zhou and Xiaoli Xue and Zhongjun Qin},
  journal={Nature},
  year={2018},
  volume={560},
  pages={331-335}
}
Eukaryotic genomes are generally organized in multiple chromosomes. Here we have created a functional single-chromosome yeast from a Saccharomyces cerevisiae haploid cell containing sixteen linear chromosomes, by successive end-to-end chromosome fusions and centromere deletions. The fusion of sixteen native linear chromosomes into a single chromosome results in marked changes to the global three-dimensional structure of the chromosome due to the loss of all centromere-associated inter… 
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