Creating 3D angiogenic growth factor gradients in fibrous constructs to guide fast angiogenesis.

@article{Guo2012Creating3A,
  title={Creating 3D angiogenic growth factor gradients in fibrous constructs to guide fast angiogenesis.},
  author={Xiaolei Guo and Christopher G. Elliott and Zhenqing Li and Yanyi Xu and Douglas W. Hamilton and Jianjun Guan},
  journal={Biomacromolecules},
  year={2012},
  volume={13 10},
  pages={3262-71}
}
Fast angiogenesis in 3D fibrous constructs that mimic the morphology of the extracellular matrix remains challenging due to limited porosity in the densely packed constructs. We investigated whether mimicking the in vivo chemotaxis microenvironment for native blood vessel formation would stimulate angiogenesis in the fibrous constructs. The chemotaxis microenvironment was created by introducing 3D angiogenic growth factor gradients into the constructs. We have developed a technique that can… CONTINUE READING

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