Creatine transport in cultured cells of rat and mouse brain.

  title={Creatine transport in cultured cells of rat and mouse brain.},
  author={Achim M{\"o}ller and Bernd Hamprecht},
  journal={Journal of neurochemistry},
  volume={52 2},
Astroglia-rich cultures derived from brains of newborn rats or mice use a transport system for the uptake of creatine. The uptake system is saturable, Na+-dependent, and highly specific for creatine and Na+. Kinetic studies on rat cells revealed a Km value for creatine of 45 microM, a Vmax of 17 nmol x h-1 x (mg of protein)-1, and a Km value of 55 mM for Na+. The carrier is competitively inhibited by guanidinopropionate (Ki = 15 microM). No such transport system was found in neuron-rich primary… CONTINUE READING

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