Creatine supplementation lowers brain glutamate levels in Huntington’s disease

@article{Bender2005CreatineSL,
  title={Creatine supplementation lowers brain glutamate levels in Huntington’s disease},
  author={Andreas Bender and Dorothee P. Auer and Thomas Merl and Ralf Reilmann and P. Saemann and Alexander Yassouridis and J Bender and Adolf Weindl and Matthias Dose and Thomas Gasser and Thomas Klopstock},
  journal={Journal of Neurology},
  year={2005},
  volume={252},
  pages={36-41}
}
AbstractThere is evidence from in vitro and animal experiments that oral creatine (Cr) supplementation might prevent or slow down neurodegeneration in Huntington’s disease (HD). However, this neuroprotective effect could not be replicated in clinical trials, possibly owing to treatment periods being too short to impact on clinical endpoints. We used proton magnetic resonance spectroscopy (1H-MRS) as a surrogate marker to evaluate the effect of Cr supplementation on brain metabolite levels in HD… Expand
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