Creatine supplementation improves intracellular Ca2+ handling and survival in mdx skeletal muscle cells.

@article{Pulido1998CreatineSI,
  title={Creatine supplementation improves intracellular Ca2+ handling and survival in mdx skeletal muscle cells.},
  author={Stephen Pulido and A. C. Passaquin and W J Leijendekker and Corinne Challet and Theo Wallimann and Urs T. R{\"u}egg},
  journal={FEBS letters},
  year={1998},
  volume={439 3},
  pages={357-62}
}
Dystrophic skeletal muscle cells from Duchenne muscular dystrophy (DMD) patients and mdx mice exhibit elevated cytosolic Ca2+ concentrations ([Ca2+]c). Pretreatment of mdr myotubes for 6-12 days with creatine (20 mM) decreased the elevation in [Ca2+]c induced by either high extracellular Ca2+ concentrations or hypo-osmotic stress to control levels. 45Ca2+ influx measurements suggest that creatine lowered [Ca2+]c by stimulating sarcoplasmic reticulum Ca2+-ATPase. Creatine pretreatment increased… CONTINUE READING
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