Creatine prevents behavioral alterations caused by methylmalonic acid administration into the hippocampus of rats in the open field task.

Abstract

Although a variable degree of psychomotor delay/mental retardation is found in a considerable number of patients affected by methylmalonic acidemia, the mechanisms underlying the neuropathology of this disorder are still poorly defined. The present study investigated the effect of acute intrahippocampal administration of methylmalonic acid (MMA), the… (More)

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