Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study

@article{Walter2000CreatineMI,
  title={Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study},
  author={Maggie C. Walter and Hanns Lochm{\"u}ller and Peter Reilich and Thomas Klopstock and R Huber and Manfred Hartard and Michael Hennig and Dieter E. Pongratz and Wolfgang M{\"u}ller-Felber},
  journal={Neurology},
  year={2000},
  volume={54},
  pages={1848 - 1850}
}
Article abstract The authors assessed the safety and efficacy of creatine monohydrate (Cr) in various types of muscular dystrophies in a double-blind, crossover trial. Thirty-six patients (12 patients with facioscapulohumeral dystrophy, 10 patients with Becker dystrophy, 8 patients with Duchenne dystrophy, and 6 patients with sarcoglycan-deficient limb girdle muscular dystrophy) were randomized to receive Cr or placebo for 8 weeks. There was mild but significant improvement in muscle strength… Expand
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References

SHOWING 1-10 OF 12 REFERENCES
Creatine monohydrate increases strength in patients with neuromuscular disease
TLDR
Short-term creatine monohydrate increased high-intensity strength significantly in patients with neuromuscular disease and increased all measured indices in both studies. Expand
A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies
TLDR
It is concluded that creatine monohydrate increased the strength of high‐intensity anaerobic and aerobic type activities in patients with mitochondrial cytopathies but had no apparent effects upon lower intensity aerobic activities. Expand
31P NMR studies in Duchenne muscular dystrophy
To evaluate possible progressive metabolic changes in Duchenne muscular dystrophy, we used 31P nuclear magnetic resonance spectroscopy to measure high-energy phosphate compounds and phosphorylatedExpand
Treatment of inclusion‐body myositis with high‐dose intravenous immunoglobulin
TLDR
Intravenous immunoglobulin is the first treatment modality to improve the strength of some muscles in patients with this disabling inflammatory myopathy and the unexpected but encouraging results from this pilot study warrant a controlled trial. Expand
Cellular energetics of dystrophic muscle
TLDR
Raised intracellular pH thus appears to be the most characteristic abnormality in dystrophin-deficient muscle, and recovery of PCr, Pi and ADP after exercise were not impaired, suggesting that mitochondrial function is normal. Expand
Muscular dystrophy: historical overview and classification in the genetic era.
TLDR
A historical perspective is presented on the classification of the muscular dystrophies, and the underpinnings of a genetic classification that can be used both at the bedside and in the research laboratory are furnished. Expand
Effect of oral creatine supplementation on jumping and running performance.
TLDR
The results show that Cr supplementation helps to prolong the time during which the maximal rate of power output could be maintained and the time of intensive running up to exhaustion improved by 13%. Expand
Creatine supplementation improves intracellular Ca2+ handling and survival in mdx skeletal muscle cells
TLDR
Pretreatment of mdx myotubes for 6–12 days with creatine decreased the elevation in [Ca2+]c induced by either high extracellular Ca2+ concentrations or hypo‐osmotic stress to control levels and myotube formation and survival were significantly enhanced by creatine pretreatment. Expand
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis
TLDR
It was found that oral administration of creatine produced a dose-dependent improvement in motor performance and extended survival in G93A transgenic mice, and it protected mice from loss of both motor neurons and substantia nigra neurons at 120 days of age. Expand
A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Muscle Nerve 1997;20:1502–1509
  • 1997
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