Creatine kinase structural changes induced by substrates.

Abstract

Myofibrillar creatine kinase (CK) buffers the cellular ATP concentration during fluctuating ATP turnover in a muscle. In order to detect structural changes of the CK molecule due to bound substrates, the dynamics of free, ATP-bound, and ATP+creatine-bound CK were examined, using steady-state and time-resolved fluorescence spectroscopy. The intrinsic… (More)
DOI: 10.1016/j.bbapap.2008.10.018

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