Creatine in Humans with Special Reference to Creatine Supplementation

@article{Balsom1994CreatineIH,
  title={Creatine in Humans with Special Reference to Creatine Supplementation},
  author={Paul D. Balsom and Karin S{\"o}derlund and Bj{\"o}rn Ekblom},
  journal={Sports Medicine},
  year={1994},
  volume={18},
  pages={268-280}
}
SummarySince the discovery of creatine in 1832, it has fascinated scientists with its central role in skeletal muscle metabolism. In humans, over 95% of the total creatine (Crtot) content is located in skeletal muscle, of which approximately a third is in its free (Crf) form. The remainder is present in a phosphorylated (Crphos) form. Crf and Crphos levels in skeletal muscle are subject to individual variations and are influenced by factors such as muscle fibre type, age and disease, but not… 

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