Creatine for neuroprotection in neurodegenerative disease: end of story?

@article{Bender2015CreatineFN,
  title={Creatine for neuroprotection in neurodegenerative disease: end of story?},
  author={Andreas Bender and Thomas Klopstock},
  journal={Amino Acids},
  year={2015},
  volume={48},
  pages={1929-1940}
}
Creatine (Cr) is a natural compound that plays an important role in cellular energy homeostasis. In addition, it ameliorates oxidative stress, glutamatergic excitotoxicity, and apoptosis in vitro as well as in vivo. Since these pathomechanisms are implicated to play a role in several neurodegenerative diseases, Cr supplementation as a neuroprotective strategy has received a lot of attention with several positive animal studies in models of Parkinson’s disease (PD), Huntington’s disease (HD… Expand
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Investigating the effect of oral creatine supplementation on aging in 162 aged wild-type C57Bl/6J mice showed that creatine improves health and longevity in mice, and may be a promising food supplement to promote healthy human aging. Expand
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