Creatine for neuroprotection in neurodegenerative disease: end of story?

  title={Creatine for neuroprotection in neurodegenerative disease: end of story?},
  author={Andreas Bender and Thomas Klopstock},
  journal={Amino Acids},
Creatine (Cr) is a natural compound that plays an important role in cellular energy homeostasis. In addition, it ameliorates oxidative stress, glutamatergic excitotoxicity, and apoptosis in vitro as well as in vivo. Since these pathomechanisms are implicated to play a role in several neurodegenerative diseases, Cr supplementation as a neuroprotective strategy has received a lot of attention with several positive animal studies in models of Parkinson’s disease (PD), Huntington’s disease (HD… 

Creatine: a miserable life without it

The purpose of the Laufen meeting was again to bring together leading biochemists, molecular biologists, geneticists, physiologists and clinical researchers, with those directly involved in the translation of creatine research into practical applications for health, medicine and sport.

The effects of creatine supplementation on striatal neural progenitor cells depend on developmental stage

The results demonstrate that the role of Cr as a GABA-ergic differentiation factor depends on the developmental stage of striatal NPCs, while Cr-mediated neuroprotection is not significantly influenced and has potential implications for optimizing future cell replacement strategies in HD.

Structural correlates of the creatine transporter function regulation: the undiscovered country

This narrative mini-review summarizes the last three decades of research on CrT structure, function and regulation and concludes that the mechanisms that mediate Cr transport during health and disease are not understood.