Creatine depletion elicits structural, biochemical, and physiological adaptations in rat costal diaphragm.

@article{Levine1996CreatineDE,
  title={Creatine depletion elicits structural, biochemical, and physiological adaptations in rat costal diaphragm.},
  author={Seymour S. Levine and B A Tikunov and D. Yvette Henson and John J Lamanca and H Lee Sweeney},
  journal={The American journal of physiology},
  year={1996},
  volume={271 5 Pt 1},
  pages={
          C1480-6
        }
}
To elucidate adaptations elicited by creatine (Cr) depletion in the costal diaphragm (Dia), 16 12-wk-old male Fisher 344 rats had 2% beta-guanidinopropionic acid (beta-GPA), a competitive inhibitor of Cr transport into muscle, added to their food; a control group (Con) of 16 rats ate normal rat chow. After 18 wk, beta-GPA and Con Dia did not differ histochemically with respect to fiber-type distribution; however, the cross-sectional area of type II(b + x) fibers was 33% less in beta-GPA than… CONTINUE READING
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