Creatine and the control of muscle-specific protein synthesis in cardiac and skeletal muscle.

@article{Ingwall1976CreatineAT,
  title={Creatine and the control of muscle-specific protein synthesis in cardiac and skeletal muscle.},
  author={J S Ingwall},
  journal={Circulation research},
  year={1976},
  volume={38 5 Suppl 1},
  pages={I115-23}
}
The observation that increased muscular activity leads to muscle hypertrophy is well known, but identification of the biochemical and physiological mechanisms by which this occurs remains an important problem. The hypothesis has been proposed that creatine, an end product of contraction, may be the chemical signal coupling increased muscular activity and increased contractile mass. Two muscle models have been used in experimental tests of this hypothesis: differentiating skeletal muscle cells… CONTINUE READING

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