Creatine Synthesis After Creatinine Loading and After Nephrectomy.∗

@article{Goldman1960CreatineSA,
  title={Creatine Synthesis After Creatinine Loading and After Nephrectomy.∗},
  author={R. Goldman and J. X. Moss},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1960},
  volume={105},
  pages={450 - 453}
}
  • R. Goldman, J. X. Moss
  • Published 1960
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine
Summary Previously, it was demonstrated that nephrectomy causes a 90% reduction in creatine synthesis in rats. In the present study, nephrectomy was found to cause a 37.5% decrease in methylation of guanidinoacetic acid (GAA)-2-C14. Rats loaded with creatinine by intraperitoneal injection demonstrated a 30% reduction in GAA methylation and a 45% reduction in total synthesis of creatine from glycine. It is concluded that chronic renal disease causes reduced creatine (and creatinine) synthesis… Expand