Creatine Supplementation in the Elderly: is Resistance Training Really Needed?

  title={Creatine Supplementation in the Elderly: is Resistance Training Really Needed?},
  author={Anna Louise Moon and Lara Heywood and Stephen Rutherford and Christian Cobbold},
Introduction: Decreases in muscle mass, strength and power are associated with ageing, all of which increase the risk of falls, and cause a loss of independence. Creatine supplementation is often used in younger athletes to improve anaerobic performance, power and strength, however the potential benefits of creatine supplementation in older individuals are less clear. With an ageing population comes age-related losses in skeletal muscle mass, sarcopenia and associated risks of falls… 

Tables from this paper

Molecular and metabolic insights of creatine supplementation on resistance training
The biochemical mechanisms of Cr ingestion in a cell signaling insight were analyzed, focusing on energetic bioavailability enhancement and optimization of the temporal and spatial buffering of Cr/PCr/CK system to explain the increase in muscle mass, strength, fatigue resistance, and performance of high intensity sports after Cr monohydrate supplementation.


Creatine supplementation: can it improve quality of life in the elderly without associated resistance training?
Data indicate that creatine supplementation without associated training in the elderly could potentially delay atrophy of muscle mass, improve endurance and strength, and increase bonestrength, and thus may be a safe therapeutic strategy to help decrease loss in functional performance of everyday tasks.
Sarcopenia: current theories and the potential beneficial effect of creatine application strategies
Emerging evidence now suggests that the timing and dosage of creatine supplementation may be important factors for aging muscle accretion, and the long-term effects of different creatine application strategies on aging muscle are relatively unknown.
Creatine supplementation improves muscular performance in older women
Short-term creatine supplementation resulted in an increase in strength, power, and lower-body motor functional performance in older women without any adverse side effects.
Creatine supplementation improves muscular performance in older men.
7 d of creatine supplementation is effective at increasing several indices of muscle performance, including functional tests in older men without adverse side effects, and may be a useful therapeutic strategy for older adults to attenuate loss in muscle strength and performance of functional living tasks.
The potential benefits of creatine and conjugated linoleic acid as adjuncts to resistance training in older adults.
  • M. TarnopolskyA. Safdar
  • Biology
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
  • 2008
These findings, and the fact that mtDNA deletions are lower and wild-type mtDNA copy number is higher after resistance training in older adults, suggests that activation of satellite cells secondary to resistance exercise-induced muscle damage can dilute or "shift" the proportion of mtDNA genotype towards that of a younger adult.
The role of progressive resistance training and nutrition in the preservation of lean body mass in the elderly.
  • R. Fielding
  • Medicine
    Journal of the American College of Nutrition
  • 1995
There is now compelling evidence that progressive resistance training in the elderly can positively influence whole body energy expenditure, muscle growth, and function and may be a powerful tool in the prevention of age-associated sarcopenia (loss of muscle mass).
Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults.
This study confirms that supervised heavy resistance exercise training can safely increase muscle strength and functional capacity in older adults and the addition of CrM supplementation to the exercise stimulus enhanced the increase in total and fat-free mass, and gains in several indices of isometric muscle strength.
Acute creatine supplementation in older men.
The data suggest that acute oral Cr supplementation does not increase isometric strength and only produces small increases in isokinetic performance and body mass in men over the age of 60.
Effects of creatine supplementation on performance and training adaptations
  • R. Kreider
  • Medicine
    Molecular and Cellular Biochemistry
  • 2004
The preponderance of scientific evidence indicates that creatine supplementation appears to be a generally effective nutritional ergogenic aid for a variety of exercise tasks in a number of athletic and clinical populations.
Resistance Exercise Reverses Aging in Human Skeletal Muscle
It is concluded that healthy older adults show evidence of mitochondrial impairment and muscle weakness, but that this can be partially reversed at the phenotypic level, and substantially reversed atThe transcriptome level, following six months of resistance exercise training.