Creatine Supplementation and Lower Limb Strength Performance: A Systematic Review and Meta-Analyses

  title={Creatine Supplementation and Lower Limb Strength Performance: A Systematic Review and Meta-Analyses},
  author={Charlotte Lanhers and Bruno Pereira and Geraldine A Naughton and Marion Trousselard and François-Xavier Lesage and Fr{\'e}d{\'e}ric Dutheil},
  journal={Sports Medicine},
BackgroundCreatine is the most widely used supplementation to increase strength performance. However, the few meta-analyses are more than 10 years old and suffer from inclusion bias such as the absence of randomization and placebo, the diversity of the inclusion criteria (aerobic/endurance, anaerobic/strength), no evaluation on specific muscles or group of muscles, and the considerable amount of conflicting results within the last decade.ObjectiveThe objective of this systematic review was to… 

Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis

Creatine supplementation is effective in upper limb strength performance for exercise with a duration of less than 3  min, independent of population characteristics, training protocols, and supplementary doses or duration.

Creatine supplementation and VO2max: a systematic review and meta-analysis.

Creatine supplementation has a negative effect on VO2max, regardless of the characteristics of training, supplementation, or population characteristics.

Effects of Creatine Supplementation on Athletic Performance in Soccer Players: A Systematic Review and Meta-Analysis

Creatine supplementation with a loading dose of 20–30 g/day, divided 3–4 times per day, ingested for 6 to 7 days, and followed by 5 g/ day for 9 weeks or with a low dose of 3 mg/kg/day for 14 days presents positive effects on improving physical performance tests related to anaerobic metabolism in soccer players.

Do multi-ingredient protein supplements augment resistance training-induced gains in skeletal muscle mass and strength? A systematic review and meta-analysis of 35 trials

When MIP supplements were combined with resistance exercise training, there were greater gains in FFM and strength in healthy adults than in counterparts who were supplemented with non-MIP.

Effects of Low-Dose Creatine Monohydrate on Muscle Strength and Endurance

These results support a number of earlier studies that demonstrated that creatine supplementation at low doses and without the use of the loading phase are effective for increasing maximal strength and endurance of upper limbs.

Effects of 4-Week Creatine Supplementation Combined with Complex Training on Muscle Damage and Sport Performance

It was concluded that creatine supplementation combined with complex training improved maximal muscular strength and reduced muscle damage during training.

Creatine Use in Sports

While creatine appears to be safe and effective for particular settings, whether creatine supplementation leads to improved performance on the field of play remains unknown.

Effect of creatine ethyl ester supplementation and resistance training on hormonal changes, body composition and muscle strength in underweight non-athlete men

It seems that the consumption of CEE combined with RT can have significant effects on body weight and leg strength in underweight non-athlete men.

Effects of Citrulline Malate Supplementation on Muscle Strength in Resistance-Trained Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The findings suggest that citrulline malate supplementation does not improve muscle strength in healthy and resistance-trained individuals.

Effects of Four Weeks of Beta-Alanine Supplementation Combined with One Week of Creatine Loading on Physical and Cognitive Performance in Military Personnel

The purpose was to investigate the effects of a 7-day creatine (Cr) loading protocol at the end of four weeks of β-alanine supplementation (BA) on physical performance, blood lactate, cognitive



Does oral creatine supplementation improve strength? A meta-analysis.

There is no evidence for improved performance in older individuals or women or for other types of strength and power exercises, and the safety of creatine remains unproven, so its use cannot be universally recommended.

Creatine supplementation during resistance training in older adults-a meta-analysis.

The results from this meta-analysis are encouraging in supporting a role for Cr supplementation during RT in healthful aging by enhancing muscle mass gain, strength, and functional performance over RT alone; however, the limited number of studies indicates further work is needed.

Long-Term Effects of Creatine Monohydrate on Strength and Power

The results indicate that 10 weeks of creatine monohydrate supplementation while participating in a resistance training program significantly increases strength and power indices compared with placebo supplementation, and indicates that lower doses of Creatine monohydrate may be ingested, without a short-term, large-dose loading phase, for an extended period to achieve significant performance enhancement.

Effect of creatine supplementation on body composition and performance: a meta-analysis.

  • J. D. Branch
  • Medicine
    International journal of sport nutrition and exercise metabolism
  • 2003
This study compared the effects of CS on effect size (ES) for body composition (BC) variables (mass and lean body mass), duration and intensity of the exercise task, type of exercise task (single, repetitive, laboratory, field, upper-body, lower-body), CS duration (loading, maintenance), and subject characteristics (gender, training status).

The effect of continuous low dose creatine supplementation on force, power, and total work.

Results indicate that Cr SUP can significantly improve factors associated with short-duration, high-intensity activity and experience significantly greater improvements in peak force and peak power.

Long-term creatine intake is beneficial to muscle performance during resistance training.

It is concluded that long-term creatine supplementation enhances the progress of muscle strength during resistance training in sedentary females.

Effect of Oral Creatine Supplementation on Near‐Maximal Strength and Repeated Sets of High‐Intensity Bench Press Exercise

It appears that 26 days of Cr supplementation significantly improves muscular strength and repeated near-maximal BP performance, and induces changes in body composition.

Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance.

There is substantial evidence to indicate that creatine supplementation during resistance training is more effective at increasing muscle strength and weightlifting performance than resistance training alone, although the response is highly variable.