Creatine Kinase–Mediated ATP Supply Fuels Actin-Based Events in Phagocytosis

@article{Kuiper2008CreatineKA,
  title={Creatine Kinase–Mediated ATP Supply Fuels Actin-Based Events in Phagocytosis },
  author={Jan W. P. Kuiper and Helma Pluk and Frank Tjj Oerlemans and Frank N van Leeuwen and Frank de Lange and Jack A. M. Fransen and B. Wieringa},
  journal={PLoS Biology},
  year={2008},
  volume={6},
  pages={453 - 465}
}
Phagocytosis requires locally coordinated cytoskeletal rearrangements driven by actin polymerization and myosin motor activity. How this actomyosin dynamics is dependent upon systems that provide access to ATP at phagosome microdomains has not been determined. We analyzed the role of brain-type creatine kinase (CK-B), an enzyme involved in high-energy phosphoryl transfer. We demonstrate that endogenous CK-B in macrophages is mobilized from the cytosolic pool and coaccumulates with F-actin at… CONTINUE READING

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