Creatine Kinase–Mediated ATP Supply Fuels Actin-Based Events in Phagocytosis

Abstract

Phagocytosis requires locally coordinated cytoskeletal rearrangements driven by actin polymerization and myosin motor activity. How this actomyosin dynamics is dependent upon systems that provide access to ATP at phagosome microdomains has not been determined. We analyzed the role of brain-type creatine kinase (CK-B), an enzyme involved in high-energy… (More)
DOI: 10.1371/journal.pbio.0060051

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