Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.

Abstract

Using the cre-loxP recombination system, we generated a line of mice expressing a constitutively active catalytic subunit of Protein Kinase A (PKA) in a temporally and spatially regulated fashion. In the absence of cre recombinase the modified catalytic subunit allele is functionally silent, but after recombination the mutant allele is expressed, resulting… (More)

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