Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.

@article{Feyerabend2011CremediatedCA,
  title={Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.},
  author={Thorsten B. Feyerabend and Anne Weiser and Annette Tietz and M. Janna Stassen and Nicola Harris and Manfred Kopf and Peter Radermacher and Peter L Moeller and C. Benoist and Diane Mathis and Hans Joerg Fehling and H. J. Rodewald},
  journal={Immunity},
  year={2011},
  volume={35 5},
  pages={832-44}
}
Immunological functions of mast cells remain poorly understood. Studies in Kit mutant mice suggest key roles for mast cells in certain antibody- and T cell-mediated autoimmune diseases. However, Kit mutations affect multiple cell types of both immune and nonimmune origin. Here, we show that targeted insertion of Cre-recombinase into the mast cell carboxypeptidase A3 locus deleted mast cells in connective and mucosal tissues by a genotoxic Trp53-dependent mechanism. Cre-mediated mast cell… CONTINUE READING