Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

  title={Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain},
  author={Benjamin E Deverman and Piers L Pravdo and Bryan P Simpson and Sripriya Ravindra Kumar and Ken Y. K. Chan and Abhik Banerjee and Wei-li Wu and Bin Yang and Nina Huber and Sergiu P. Pașca and Viviana Gradinaru},
  booktitle={Nature Biotechnology},
Recombinant adeno-associated viruses (rAAVs) are commonly used vehicles for in vivo gene transfer. However, the tropism repertoire of naturally occurring AAVs is limited, prompting a search for novel AAV capsids with desired characteristics. Here we describe a capsid selection method, called Cre recombination–based AAV targeted evolution (CREATE), that enables the development of AAV capsids that more efficiently transduce defined Cre-expressing cell populations in vivo. We use CREATE to… CONTINUE READING
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