Crawling movements of lymphocytes on and beneath fibroblasts in culture.

@article{Chang1979CrawlingMO,
  title={Crawling movements of lymphocytes on and beneath fibroblasts in culture.},
  author={Tse Wen Chang and Esteban Celis and Herman N. Eisen and Fredric Solomon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1979},
  volume={76 6},
  pages={
          2917-21
        }
}
Some lymphocytes become highly motile upon immunological stimulation in vivo or in vitro. When introduced into a culture of 3T3 or L cells and followed by live-cell microscopy, some of these lymphocytes were observed to crawl on top of, along the edges of, and preferentially beneath the attached fibroblasts. The crawling could be as rapid as 20 mum/min, easily detectable without a time-lapse device. The striking ability of crawling lymphocytes to penetrate beneath attached 3T3 cells provided a… CONTINUE READING
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