Craniosynostosis-associated gene nell-1 is regulated by runx2.

  title={Craniosynostosis-associated gene nell-1 is regulated by runx2.},
  author={Thien Truong and Xinli Zhang and Dharmini Pathmanathan and Chia Soo and K -L.H. Ting},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={22 1},
UNLABELLED We studied the transcriptional regulation of NELL-1, a craniosynostosis-related gene. We identitifed three OSE2 elements in the NELL-1 promoter that are directly bound and transactivated by Runx2. Forced expression of Runx2 induces NELL-1 expression in rat calvarial cells. INTRODUCTION We previously reported the upregulation of NELL-1 in human craniosynostosis and the overexpression of Nell-1 in transgenic animals that induced premature suture closure associated with increased… CONTINUE READING

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