Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells

  title={Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells},
  author={Marek Dud{\'a}s and Somyoth Sridurongrit and Andr{\'e} Louis Lobo Nagy and Kenji Okazaki and Vesa M Kaartinen},
  journal={Mechanisms of Development},
Neural crest cells (NCCs) are pluripotent migratory cells that contribute to the development of various craniofacial structures. Many signaling molecules have been implicated in the formation, migration and differentiation of NCCs including bone morphogenetic proteins (BMPs). BMPs signal through a receptor complex composed of type I and type II receptors. Type I receptors (Alk2, Alk3 and Alk6) are the primary determinants of signaling specificity and therefore understanding their function is… CONTINUE READING


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