Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatin.

@article{Singh2009CranberryPA,
  title={Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatin.},
  author={Ajay Singh and R. K. SINGH and Kyu Kwang Kim and K S Satyan and Roger Nussbaum and Monica Torres and Laurent Brard and Nicholi Vorsa},
  journal={Phytotherapy research : PTR},
  year={2009},
  volume={23 8},
  pages={1066-74}
}
Polyphenolic extracts of the principal flavonoid classes present in cranberry were screened in vitro for cytotoxicity against solid tumor cells lines, identifying two fractions composed principally of proanthocyanidins (PACs) with potential anticancer activity. Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry (MALDI-TOF-MS) analysis of the proanthocyanidins (PACs) fractions indicated the presence of A-type PACs with 1-4 linkages containing between 2-8 epicatechin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

The Immunological Basis of Placental Function and Diseases: The Placenta, Fetal Membranes and Umbilical Cord.

  • S Kalkunte, JF Padbury, S Sharma
  • Ninth Edition,
  • 2011
1 Excerpt

Polychlorinated biphenyls (PCB) and female reproductive health : an enigmatic paradigm

  • N Tewari, S Kalkunte, J Taxton, S. Sharma
  • Indian Council of Medical Research, Govt of India…
  • 2008
1 Excerpt

Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilms

  • P Ferguson, E Kurowska, DJ Freeman, AF Chambers, DJ Koropatnick
  • FEMS Microbiol Lett
  • 2006

Cranberry phenolics : effects on oxidative processes , neuron cell death and tumor cell growth

  • RP Perez
  • Symposium Series on Phenolics in Foods and…
  • 2005

Similar Papers

Loading similar papers…