Cranberry and Urinary Tract Infections

@article{Guay2012CranberryAU,
  title={Cranberry and Urinary Tract Infections},
  author={David R. P. Guay},
  journal={Drugs},
  year={2012},
  volume={69},
  pages={775-807}
}
Urinary tract infection (UTI) refers to the presence of clinical signs and symptoms arising from the genitourinary tract plus the presence of one or more micro-organisms in the urine exceeding a threshold value for significance (ranges from 102 to 103 colony-forming units/mL). Infections are localized to the bladder (cystitis), renal parenchyma (pyelonephritis) or prostate (acute or chronic bacterial prostatitis). Single UTI episodes are very common, especially in adult women where there is a… 

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Systematic review of ten studies has reported that use of cranberry product for 12 months as compared to placebo/control significantly reduces the risk of UTI by 65% (95% CI: 0.46-0.90).4 Cranberry products were found to be more effective in women with recurrent UTI than in elderly men or patients requiring catheterization.

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The overall use of non-antibiotic methods for prevention of recurrent UTI, including the use of immunostimulant OM-89, a vaginal vaccine or estrogen, lactobacilli prophylaxis, and cranberry are discussed.

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References

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A meta-analysis arrived at the conclusion that antibiotic prophylaxis is associated with a meaningful reduction in the risk of UTI infection, and the peculiar characteristics of this natural element and its possible use in the prevention ofUTI are introduced.

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The ever-increasing incidence of antimicrobial resistance of the common uropathogens in uUTI has been and is a continuing focus of intensive study, resulting in substantial cost savings.

Can a concentrated cranberry extract prevent recurrent urinary tract infections in women? A pilot study.

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Liquid cranberry products, on a daily basis, at the dosage employed, did not have any effect greater than that of water in preventing urinary tract infections in this pediatric neuropathic bladder population.

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The findings will allow older women with recurrent UTIs to weigh up with their clinicians the inherent attractions of a cheap, natural product like cranberry extract whose use does not carry the risk of antimicrobial resistance or super- infection with Clostridium difficile or fungi.

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Cranberries are widely used in the treatment and prevention of urinary tract infections (UTIs) and for those at risk of such infections and are thought to be the key factors in inhibiting E. coli adherence.

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