Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents

  title={Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents},
  author={Katherine M Weh and Jennifer Clarke and Laura A. Kresty},
Cranberries are rich in bioactive constituents reported to influence a variety of health benefits, ranging from improved immune function and decreased infections to reduced cardiovascular disease and more recently cancer inhibition. A review of cranberry research targeting cancer revealed positive effects of cranberries or cranberry derived constituents against 17 different cancers utilizing a variety of in vitro techniques, whereas in vivo studies supported the inhibitory action of cranberries… 

Cranberry as a Promising Natural Source of Potential Nutraceuticals with Anticancer Activity.

The present study aims to critically summarise the existing experimental studies evaluating the potential effects of cranberry on cancer prevention and treatment and could be considered as a conglomeration of potential effective anticancer drug-like compounds.

Cranberry anti-cancer compounds and their uptake and metabolism: An updated review

Poor plasma bioavailability of cranberry constituents may be overcome by their potential interactions with gut microbiota by providing cancer prevention through induction of compositional and functional modifications of gut microbiota.

Cranberry Polyphenols in Esophageal Cancer Inhibition: New Insights

Viability results show that C-PAC is more potent than AFG at inducing cell death in BE and EAC cell lines, andBioinformatic analysis of RPPA results revealed many previously unidentified pathways as modulated by cranberry polyphenols including NOTCH signaling, immune response, and epithelial to mesenchymal transition.

Various Promising Biological Effects of Cranberry Extract: A Review

Cranberry is a well-known natural occurring product that has been used for centuries in traditional medicine to promote urinary tract health. Besides that, Cranberry has shown promising biomedicinal

Cranberry Extract Is a Potent Radiosensitizer for Glioblastoma

Investigating if cranberry extract (CE) sensitizes GBM to RT in the widely used human glioblastoma cell line U87 found that CE alone had little effect on the survival of U87 cells, however, RT supplemented by CE significantly inhibited proliferation and promoted apoptosis of U 87 cells when compared with RT alone.


It is suggested that Graviola alone or with Cranberry could be used as a source of natural anti-proliferative agent and thus could be useful as anti-tumor agent against colorectal cancer cells and is worth further investigation.

Anticancer Phytocompounds

Cure lies in nature: medicinal plants and endophytic fungi in curbing cancer

The perspective advocates the imperative role of anti-cancerous secondary metabolites containing repository of endophytic fungi, as an alternative route of drug discovery.

Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model

It is shown that daily administration of CJE induces distinct dynamical patterns in bacterial abundances during and after treatment before recovering resiliently to pre-treatment levels, suggesting intestinal mucus accumulation due to CJE.

Cytotoxic, genotoxic and apoptotic effects of Viburnum opulus on colon cancer cells: an in vitro study

In vitro research clearly demonstrated that V. opulus methanolic extract induces DNA damage, apoptosis, and cytotoxicity in a dose-dependent manner in cancer cells due to its pro-oxidant activity.



Cranberry Proanthocyanidins Mediate Growth Arrest of Lung Cancer Cells through Modulation of Gene Expression and Rapid Induction of Apoptosis

This study investigated the ability of a proanthocyanidin rich cranberry fraction (PAC) to alter gene expression, induce apoptosis and impact the cell cycle machinery of human NCI-H460 lung cancer cells.

Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells.

The findings suggest that PAC-1 exerts potent anticancer and anti-angiogenic properties and that highly purified PAC from cranberry can be further developed to treat ovarian cancer in combinational or single-agent therapy.

Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases.

  • C. Neto
  • Biology, Medicine
    Molecular nutrition & food research
  • 2007
The evidence suggests a potential role for dietary cranberry and blueberry in the prevention of cancer and vascular diseases, justifying further research to determine how the bioavailability and metabolism of berry phytonutrients influence their activity in vivo.

Black raspberries in cancer clinical trials: Past, present and future

Clinical investigations targeting cancer or precancerous lesions with BRB and common themes across studies support that BRB are anti-proliferative, anti- inflammatory, reduce oxidative stress and restore tumor suppressive activity.

Cranberry and Grape Seed Extracts Inhibit the Proliferative Phenotype of Oral Squamous Cell Carcinomas

Comparisons provide evidence that cranberry and grape seed extracts not only inhibit oral cancer proliferation but also that the mechanism of this inhibition may function by triggering key apoptotic regulators in these cell lines.

Cranberries and Their Bioactive Constituents in Human Health12

Evidence suggesting that cranberries may decrease the recurrence of urinary tract infections is important because a nutritional approach to this condition could lower the use of antibiotic treatment and the consequent development of resistance to these drugs.

Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation

C-PAC is a potent inducer of EAC cell death and is efficacious in vivo at non-toxic behaviorally achievable concentrations, holding promise for preventive or therapeutic interventions in cohorts at increased risk for EAC, a rapidly rising and extremely deadly malignancy.

North American Cranberry (Vaccinium Macrocarpon) Stimulates Apoptotic Pathways in DU145 Human Prostate Cancer Cells In Vitro

It is indicated that cranberry phytochemicals can induce apoptosis in prostate cancer cells in vitro, and these findings further establish the potential value of cranberries phytochemicalicals as possible agents against prostate cancer.

Phytochemicals of Cranberries and Cranberry Products: Characterization, Potential Health Effects, and Processing Stability

This review focuses on Vaccinium macrocarpon, the American cranberry, compiling a comprehensive list of its known phytochemical components, and detailing their prevalence in cranberry fruit and its products.

A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines.

Fraction 6 was shown in MDA-MB-435 cells to block cell cycle progression and induce cells to undergo apoptosis in a dose-dependent manner, and is potentially a source of a novel anticancer agent.