Cramps, spasms and muscle stiffness.

  title={Cramps, spasms and muscle stiffness.},
  author={Lewis P. Rowland},
  journal={Revue neurologique},
  volume={141 4},
Cramp syndromes pose a challenge for neuroscientists. The motor disorders of Isaacs syndrome have been ascribed to peripheral neuropathy, and sometimes there is ample supporting evidence of neuropathy. However, signs of overt neuropathy are found in a minority of cases and the essential findings (carpal and pedal spasm, pseudomyotonia and myokymia) may arise from abnormal excitability of the perikaryon because similar manifestations are seen in tetany and multiple sclerosis. The Moersch-Woltman… CONTINUE READING


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