CpG oligodeoxynucleotides induce the expression of the antimicrobial peptide cathelicidin in glial cells.

@article{Brandenburg2013CpGOI,
  title={CpG oligodeoxynucleotides induce the expression of the antimicrobial peptide cathelicidin in glial cells.},
  author={Lars-Ove Brandenburg and Sandra Jansen and Lea-Jessica Albrecht and Julika Merres and Joachim Gerber and Thomas Pufe and Simone C Tauber},
  journal={Journal of neuroimmunology},
  year={2013},
  volume={255 1-2},
  pages={18-31}
}
During bacterial infections, antimicrobial peptides are synthesised as an important part of the innate immune system. However, expression and function in the central nervous system (CNS) need further investigations. The aim of this study was to examine the involvement of the pattern-recognition-receptor toll-like receptor 9 (TLR9) in the expression of the cathelin-related antimicrobial peptide (CRAMP) and to characterise the participating signal transduction pathways. In primary TLR9 deficient… CONTINUE READING
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