CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kappaB activation.

@article{Lee2004CpGOI,
  title={CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kappaB activation.},
  author={Soojin Lee and Jinpyo Hong and Se-Young Choi and Seog Bae Oh and Kyungpyo Park and Joong Soo Kim and Michael Karin and Sung Joong Lee},
  journal={Journal of neuroimmunology},
  year={2004},
  volume={153 1-2},
  pages={50-63}
}
Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs stimulate the cells of the innate immune system through a specific receptor called Toll-like receptor-9 (TLR9). It was reported that CpG ODN stimulation induces activation of astrocytes and microglia. However, the precise intracellular signaling pathways that lead to this glial cell activation have not been clearly elucidated. In this study, we found that CpG ODN induce mRNA expression of adhesion… CONTINUE READING
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