CpG oligodeoxynucleotides down-regulate macrophage class II MHC antigen processing.

@article{Chu1999CpGOD,
  title={CpG oligodeoxynucleotides down-regulate macrophage class II MHC antigen processing.},
  author={Raymond K. S. Chu and David Askew and Erika H. Noss and Aaron A. R. Tobian and Arthur M. Krieg and Clifford V Harding},
  journal={Journal of immunology},
  year={1999},
  volume={163 3},
  pages={1188-94}
}
Unmethylated CpG motifs in bacterial DNA or short oligodeoxynucleotides (ODN) stimulate cells of the immune system and provide adjuvant activity. CpG DNA directly activates macrophages to secrete IL-12 and TNF-alpha and increases transcription of various genes, but its effects on macrophage Ag processing remain uncertain. The effects of CpG ODN on class II MHC (MHC-II) Ag processing and presentation were examined using peritoneal macrophages that were cultured for 18 h with CpG ODN and then… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…