CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma.

@article{Kline1999CpGOD,
  title={CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma.},
  author={J. Nathan Kline and Arthur M. Krieg and Thomas J Waldschmidt and Zuhair K. Ballas and Viney Kumar Jain and Thomas R. Businga},
  journal={The Journal of allergy and clinical immunology},
  year={1999},
  volume={104 6},
  pages={1258-64}
}
BACKGROUND Oligodeoxynucleotides (ODNs) containing the dinucleotide CpG in a specific sequence context (CpG-ODNs) have the ability to prevent the development of eosinophilic airway inflammation and bronchial hyperreactivity in a murine model of asthma. We have previously demonstrated that CpG-ODNs stimulate expression of the T(H1)-inducing cytokines IFN-gamma and IL-12 in a murine model of asthma and that this stimulation is associated with the protection against asthmatic inflammation… CONTINUE READING
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