CpG motifs in bacterial DNA trigger direct B-cell activation

@article{Krieg1995CpGMI,
  title={CpG motifs in bacterial DNA trigger direct B-cell activation},
  author={Arthur M. Krieg and A E Yi and Sara Matson and Thomas J Waldschmidt and Gail Abendroth Bishop and Rebecca Teasdale and Gary A Koretzky and Dennis M Klinman},
  journal={Nature},
  year={1995},
  volume={374},
  pages={546-549}
}
UNMETHYLATED CpG dinucleotides are more frequent in the gen-omes of bacteria and viruses than of vertebrates. We report here that bacterial DNA and synthetic oligodeoxynucleotides containing unmethylated CpG dinucleotides induce murine B cells to proliferate and secrete immunoglobulin in vitro and in vivo. This activation is enhanced by simultaneous signals delivered through the antigen receptor. Optimal B-cell activation requires a DNA motif in which an unmethylated CpG dinucleotide is flanked… CONTINUE READING
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