CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection

@article{Matsukura2003CpGMO,
  title={CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection},
  author={Shiroh Matsukura and Hidenobu Soejima and Tetsuji Nakagawachi and Hiroyuki Yakushiji and Akiomi Ogawa and Masayo Fukuhara and Keiko Miyazaki and Yusaku Nakabeppu and Mutsuo Sekiguchi and Tsunehiro Mukai},
  journal={British Journal of Cancer},
  year={2003},
  volume={88},
  pages={521 - 529}
}
Inactivations of DNA repair genes, O6-methylguanine-DNA methyltransferase (MGMT) and hMLH1, by promoter hypermethylation have been reported in several types of primary human neoplasia. This epigenetic inactivation mechanism remains elusive in hepatocellular carcinoma (HCC). To investigate the relation between the expression of MGMT and hMLH1 and the CpG methylation within their promoters in HCCs with or without hepatitis viral infection, we performed immunohistochemistry and urea/bisulphite… CONTINUE READING

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