CpG island structure and trithorax/polycomb chromatin domains in human cells.

@article{Orlando2012CpGIS,
  title={CpG island structure and trithorax/polycomb chromatin domains in human cells.},
  author={David A. Orlando and Matthew G. Guenther and Garrett M. Frampton and Richard A. Young},
  journal={Genomics},
  year={2012},
  volume={100 5},
  pages={320-6}
}
TrxG and PcG complexes play key roles in the epigenetic regulation of development through H3K4me3 and H3K27me3 modification at specific sites throughout the human genome, but how these sites are selected is poorly understood. We find that in pluripotent cells, clustered CpG-islands at genes predict occupancy of H3K4me3 and H3K27me3, and these "bivalent" chromatin domains precisely span the boundaries of CpG-island clusters. These relationships are specific to pluripotent stem cells and are not… CONTINUE READING
19 Citations
55 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Similar Papers

Loading similar papers…