CpG island methylator phenotype-positive tumors in the absence of MLH1 methylation constitute a distinct subset of duodenal adenocarcinomas and are associated with poor prognosis.

@article{Fu2012CpGIM,
  title={CpG island methylator phenotype-positive tumors in the absence of MLH1 methylation constitute a distinct subset of duodenal adenocarcinomas and are associated with poor prognosis.},
  author={Tao Fu and Emmanouil P. Pappou and Angela A. Guzzetta and Jana Jeschke and Ruby Kwak and Pujan Dave and Craig Mitchell Hooker and Richard Alan Morgan and Stephen B. Baylin and Christine A Iacobuzio-Donahue and Christopher L. Wolfgang and Nita Ahuja},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 17},
  pages={
          4743-52
        }
}
PURPOSE Little information is available on genetic and epigenetic changes in duodenal adenocarcinomas. The purpose was to identify possible subsets of duodenal adenocarcinomas based on microsatellite instability (MSI), DNA methylation, mutations in the KRAS and BRAF genes, clinicopathologic features, and prognosis. EXPERIMENTAL DESIGN Demographics, tumor characteristics, and survival were available for 99 duodenal adenocarcinoma patients. Testing for KRAS and BRAF mutations, MSI, MLH1… CONTINUE READING
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