CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer.

@article{Cheng2008CpGIM,
  title={CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer.},
  author={Yu-Wei Cheng and Hanna Pincas and Manny D. Bacolod and Gunter S Schemmann and Sarah F. Giardina and Jianmin Huang and Sandra M Barral and Kamran Idrees and Sajid A. Khan and Zhaoshi Zeng and Shoshana M Rosenberg and Daniel A. Notterman and J{\"u}rg Ott and P Phillip Paty and Francis Barany},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 19},
  pages={6005-13}
}
PURPOSE Aberrant promoter methylation and genomic instability occur frequently during colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown to associate with microsatellite instability, and BRAF mutation and is often found in the right-side colon. Nevertheless, the relative importance of CIMP and chromosomal instability (CIN) for tumorigenesis has yet to be thoroughly investigated in sporadic colorectal cancers. EXPERIMENTAL DESIGN We determined CIMP in 161… CONTINUE READING
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Chromo - somal instability in microsatellite - unstable and stable colon cancer

  • K Trautmann, TerdimanJP, AJ French
  • Clin Cancer Res
  • 2006

Chromosom - al instability correlates with genome - wide dna demethylation in human primary colorectal cancers

  • FrigolaJ RodriguezJ, E Vendrell
  • Cancer Res
  • 2006

Evalua - tion of a large , population - based sample supports a CpG island methylator phenotype in colon cancer

  • SamowitzWS, HerrickJ Albertsen H
  • Gastroenterology
  • 2005

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