CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer.

@article{Kim2006CpGIM,
  title={CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer.},
  author={Y. H. Kim and Zsolt Petko and Slavomir Dzieciatkowski and Li Lin and Mahan Ghiassi and Steve Stain and William C. Chapman and M. Kay Washington and Joseph Willis and Sanford D Markowitz and William M. Grady},
  journal={Genes, chromosomes & cancer},
  year={2006},
  volume={45 8},
  pages={781-9}
}
Genetic alterations occur during the adenoma-carcinoma sequence of colon cancer formation and drive the initiation and progression of colon cancer formation. The aberrant methylation of genes is an alternate, epigenetic mechanism for silencing tumor suppressor genes in colon cancer. The aim of this study was to determine on a global and gene-specific level the role of CpG island methylation in the initiation and progression of colon cancer. Consequently, we assessed the frequency of gene… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Similar Papers

Loading similar papers…